CODENSE is a software package to mine coherent dense subgraphs from multiple biological networks. CODENSE is short for Mining Coherent Dense Subgraphs. By simplifying the problem of identifying coherent dense subgraphs across n graphs into a problem of identifying dense subgraphs in two special graphs: the summary graph and the second-order graph, CODENSE can efficiently mine frequent coherent dense subgraphs across large numbers of massive graphs.